Page 32 - Gates-AnnualReport-2017

PROGRESS REPORTS FROM 2016 GRUBSTAKE FUND RECIPIENTS
• Jeffrey Olsen, M.D.: Intraocular Device to Potentiate Retinal Stem Cell Transplantation in Macular Degeneration
° In vitro testing of implant completed; 40-fold improvement in trapped pathologic proteins.
° Built and tested a working prototype ex vivo in an eye bank eye for surgical placement.
° Created a smaller mouse-sized prototype for animal studies.
° Additional ex vivo and animal studies underway.
° Regulatory and manufacturing activities are ongoing.
• Ken Liechty, M.D.: Nanoceria for the Treatment of Diabetic Foot Ulcers
° Validated preliminary data of improved wound healing in diabetic mice.
° Generated positive preliminary data for wound healing in a porcine model of diabetes.
° Working with regulatory consultants to prepare a pre-IND regulatory package.
° Preliminary nonclinical and toxicology studies are almost complete.
• David Wagner, Ph.D.: A 15-amino acid Peptide to potentially Stop Demyelination and Restore Myelin Production in Multiple Sclerosis
° Confirmed the pathological cell type in mouse models as Th40 cells.
° Confirmed elevated levels of Th40 cells in the peripheral blood of MS patients.
° Identified a lead candidate for drug development, KGYY6, in a preventative mouse model.
° Testing of lead candidate in treatment model of MS is ongoing.
PAST GATES GRUBSTAKE FUND AWARDEES
2014
• Xiao-Jing Wang, M.D., Ph.D.: Human Smad7-based proteins combined with a cell permeable peptide called Tat. Tat-Smad7
and its derivatives can be used via topical application to treat at least four diseases: oral mucositis, psoriasis, chronic
wounds, and fibrotic diseases.
• Antonio Jimeno, M.D., Ph.D.: Proprietary humanized mouse model to assess cancer treatments 2015
• Ganna Bilousova, Ph.D., and Igor Kogut, Ph.D.: Induced pluripotent stem cell services as a platform for clinical research
• Steven Dow, DVM, Ph.D., and Mary Ann DeGroote, M.D.: Antimicrobial stem cell therapy for infected diabetic foot ulcers
• Karin Payne, Ph.D., and Vikas Patel, M.D.: Structural living bone allografts to enhance bone formation in orthopedic surgery 2016
• Jeffrey Olsen, M.D.: Intraocular device to potentiate retinal stem cell transplantation in macular degeneration
• Ken Liechty, M.D.: A platform technology useful for treating a variety of diseases where inflammation and oxidative stress
are pathognomonic in the progression of the disease; initial focus is treatment of diabetic ulcers, where compelling in vitro
and animal model data exists showing that treatment results in closure rates of diabetic wounds equal to nondiabetic wounds
• David Wagner, Ph.D.: A 15-amino acid peptide to potentially stop demyelination and restore myelin production in
multiple sclerosis
32 Gates Center for Regenerative Medicine