Page 24 - Randlab Global Product Brochure

Sedative and Analgesic
sedatorTM seDAtIVe/ANALGesIC FOR CAttLe AND HORses
ACVM No. A011244 (New Zealand)
For mild to heavy sedation and for analgesia in cattle and horses and for control of pain in
uncomplicated colic in horses
ACTIVE CONSTITUENT
Detomidine Hydrochloride 10 mg/mL
PACK SIZE
5mL single vial
Indications
Sedator is a dose controlled sedative and analgesic. It may be used to facilitate examinations, x-rays, minor surgical operations, transport etc. It may be used to control pain including that of the uncomplicated equine colic case.
Sedator has a role in providing prolonged analgesia (upto 12 hours) in horses for example with an accident case. For analgesia in COLIC in horses the recommended dose is 20- 40μg/kg BW (0.2-0.4mL/kg BW) until diagnosis is confirmed.
Sedator is a sedative and analgesic that may be used to facilitate:
• Examinations e.g. Endoscopy, rectal palpation, gynaecological examinations and x-rays. • Minor surgical procedures e.g. Treatment of wounds, removal of skin tumours, hoof
care and castration.
• Treatment and medication e.g. use of nasogastric tube and shoeing.
In painful procedures detomidine should be used in combination with an analgesic or a local anaesthetic.
Contraindications
As the safety of Sedator during pregnancy and lactation has not been adequately documented, its use is not recommended during the last month of pregnancy. Intravenous potentiated sulphonamides are contraindicated in sedated or anaesthetised horses as potentially fatal dysrhythmias may occur.
Precautions
Sedator may cause penile relaxation. Use with caution on male animals, particularly during breeding. Clinicians should anticipate the occasional tendency of the animal’s head to drop under the influence of Sedator and the subject should be accommodated appropriately. Immediately following administration there may be a tendency to stagger, particularly if
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high dose rates are employed. Fasting prior to Sedator sedation is not necessary. The animal should not be fed until the effect of the drug has worn off. The safe handling of horses and cattle can be improved with Sedator. Although the animal is easy to handle under Sedator sedation, normal restricting methods are recommended. Local anaesthetics can be used when required for painful procedures, particularly surgery, as the duration of analgesia from Sedator may not equate with the duration of sedation. A risk/benefit assessment should be undertaken by a veterinarian before using this product in animals suffering from cardiac disease (with pre-existing bradycardia and risk of atrioventricular block), respiratory, liver or renal insufficiencies or shock. If cattle lie down avoid ruminal bloat and aspiration of feed or saliva by maintaining in sternal recumbency during and following treatment with head and neck lowered.
Overdosage and Side Effects
The symptoms may be relieved by atropine or specific alpha-2 antagonist. Harmful side effects have not been observed. Sym- pathomimetic properties, particularly at higher doses, may include piloerection, sweating, diuresis and occasional slight tremors.
Dosage And Administration
HORSES AND CATTLE: Administration is by slow intravenous or the intramuscular route.
Dose
Effect
Effects begin (mins)
Duration of action (hrs)
Other effects
μg/ kg
mL/ 100 kg
10-20
0.1-0.2
Easy to handle
3-5
0.3-1.0
Slight teetering
20-40
0.2-0.4
Easy to handle
3-5
0.5-1.0
Slight teetering
40-80
0.4-0.8
Prolonged effect
2-5
0.5-2.0
Teetering, sweating, piloerection, muscle spasms
80-150
0.8-1.5
Strong effect
1-5
2.0-6.0
Strong teetering, sweating, piloerection
The effects begin soon after IV administration. Tissue tolerance to Sedator is good. For analgesia in COLIC until diagnosis is confirmed, recommended dose is 20 – 40 μg/kg BW (0.2 – 0.4 mL/100 kg BW). The full analgesic effect is established by 5 – 15 minutes following administration. If the desired level of sedation is not achieved following administration of a low dose, a further, additive, dose may be given. When using Sedator extra fuss should be avoided.
Meat Withholding Period: It is an offence for users of this product to cause residues exceeding the relevant MRL in the New Zealand (Maximum Residues of Agricultural Compounds) Food Standards.
Cattle: Meat: Nil; Milk: Nil. Horses: Meat: Nil
Racing/Event Withholding Period: If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.
First Aid: If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131126 or in New Zealand 0800 764 766.
Disposal: Dispose of empty container or expired product by wrapping with paper and putting in garbage.
Storage: Store below 25°C (air conditioning). Protect from light. In-use shelf life: 11 weeks from initial broaching.
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