Page 19 - Randlab Global Brochure Australian Edition

ANTI-INFLAMMATORY
Colix InjectionTM
NSAID for the alleviation of inflammation and pain of the gastrointestinal, musculoskeletal and ocular systems and the treatment of endotoxic shock APVMA Approval No. 68287/57947 (Australia) | ACVM No. A011471 (New Zealand)
Potent analgestic for the control of severe intestinal pain and musculoskeletal and occular disorders.
ACTIVE CONSTITUENT
Flunixin Meglumine
equivalent to Flunixin 50 mg/mL
PACK SIZE 100mL vial
INDICATIONS
For the alleviation of inflammation and pain associated with musculoskeletal disorders and for the alleviation of visceral pain and inflammation associated with colic. Also aids the normalisation of peristalsis.
For the treatment of inflammatory ocular conditions such as uvelitis and pre- and post- eye surgery.
At lower doses than used for anti-inflammatory effects, flunixin reduces the haemodynamic changes associated with endotoxaemia / endotoxic shock.
DOSAGE AND ADMINISTRATION
Injection reactions may develop following intramuscular injections of flunixin in horses and should be avoided.
Musculoskeletal disorders: 1.1 mg per kg (1mL/45kg) bodyweight one to three times daily by intravenous injection for up to 5 days.
Alleviation of pain associated with colic: 1.1 mg per kg bodyweight I.V administration is recommended for prompt relief. May be repeated if signs of colic recur. Cause of colic should be determined and treated with appropriate therapy.
In cases of endotoxaemia or at risk of endotoxaemia a dose of 0.25mg/kg q8h can be administered IV to interrupt eicosanoid production and inhibit the associated endotoxin-induced haemodynamic effects.
PRECAUTIONS
Prolonged detection times leading to a positive drug test have been reported in the horse. This is believed to be due to drug “recycling” with the horse ingesting previously excreted flunixin. It is recommended that boxed competition horses be moved to a different stall after the normal excretion period (~96 hours).
In horses with colic, flunixin may mask the behavioural and cardiopulmonary signs associated with endotoxaemia or intestinal devitalisation. In the absence of any specific studies in pregnant animals, such use is not recommended. Concurrent use with other anti-inflammatory drugs should be avoided. Use with caution in animals with renal, hepatic or haematologic disease. Excessive doses or prolonged administration may result in gastrointestinal (right dorsal colon or stomach) ulceration. Avoid intramuscular administration in the horse.
“Harness mules and oxen but give a horse a chance to run”. Wild Bill Hickok (Hero of the American Old West whose occupations are variably listed as drover, wagon master, soldier, spy, scout, lawman, gunfighter, gambler, showman, and actor).
Racing/Event Withholding Period: If used in performance animals, the regulations of the relevant authorities regarding medication should be observed.
First Aid: If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131126 or in New Zealand 0800 764 766.
Disposal: Dispose of empty container by wrapping with paper and putting in garbage. Discarded needles/ sharps should immediately be placed in a designated and appropriately labelled “sharps” container.
Storage: Store below 30°C (Room Temperature). Do not freeze.
HORSE HACK: Flunixin Injection may be administered orally at a dose rate of 1.1-1.3mg/kg. The injection can be administered mixed with molasses or squirted directly over the back of the horse’s tongue. The onset of action after oral dosing is generally within 2 hours, peak response 12-16 hours and duration of action up to 30 hours.
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