Page 8 - Randlab Global Brochure Australian Edition
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ULCER TREATMENTS
Ulcershield® Oral Paste
Omeprazole paste for treatment and prevention of gastric ulcers
APVMA Approval No. 81799/104073 (Australia) | ACVM No. A10916 (New Zealand)
Always administer Ulcershield on a relatively empty stomach. Administer a minimum of 20 minutes prior to feeding.
25% better absorption than competitors in 3 x University trials.
ACTIVE CONSTITUENT Omeprazole 370 mg/g Buffered Paste
PACK SIZE
Pack of 6 x 33g multi-dose syringes
INDICATIONS
For the treatment and prevention of gastric ulcers in the horse. Clinical signs of gastric ulceration include depressed appetite, behavioural changes, poor hair coat, recurrent low grade colic, intermittent loose faeces, chronic diarrhoea, poor body condition and poor performance. FOALS: Signs in foals include depressed appetite or inappetence, teeth grinding, dribbling saliva, colic, diarrhoea, sternal recumbency, dog sitting or weakness.
of Ulcershield for longer than 91 days treatment has not been determined in clinical studies. Complications of long-term administration of omeprazole have not been reported in the horse. Ulcershield can be used concomitantly with other medications including anthelmintics, antibiotics, non-steroidal anti-inflammatories and other commonly administered veterinary preparations.
DIRECTIONS FOR USE
After administering the initial dose use remaining product within 1 month.
DOSAGE AND ADMINISTRATION
Treatment Dose: 4 mg/kg.
Adult horses (600 kg) give 6 mL (1 mL per 100 kg) daily for 28 days.
Prevention/Maintenance Dose: 1 mg/kg.
Adult horses (600 kg) give 1.5 mL (0.25 mL per 100 kg) daily for 28 days.
The product is very sticky so ensure that it is applied onto the internal parts of the mouth, not just dropped into the oral cavity. Immediately raise the horse’s head for a few seconds after dosing to ensure the full dose has been swallowed.
“A horse doesn’t care how much you know until he knows how much you care. Put your hand on your horse and your heart in your hand.”
Pat Parelli (legendary American horse whisperer
and founder of the Natural Horsemanship movement).
Clinical signs of gastric ulceration include: • depressed appetite
• behavioural changes
• poor hair coat
• recurrent low grade colic
PHARMACOLOGY
• intermittent loose faeces • chronic diarrhoea
• poor body condition
• poor performance
For accurate diagnosis of gastric ulcers, direct endoscopic examination of the gastric mucosa (gastroscopy) is recommended.
The maintenance dose may be insufficient to prevent the recurrence of ulceration in horses subjected to increased stress such as intense training, heavy competition schedule, transport, etc. In such cases, a dose of 2mg/kg (3.0mL for a 600 kg horse) is recommended.
Omeprazole is a proton-pump inhibitor. Omeprazole suppresses gastric acid by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Omeprazole will block gastric acid secretion irrespective of the stimulus. Maximum acid suppression occurs after 3-5 days of treatment.
SAFETY TO HORSES
Ulcershield has a wide safety margin in horses and foals and can be used in foals from one month old. Ulcershield can be safely administered to stallions used for breeding. Safety in pregnant or lactating mares has not been established. The safety
HORSE HACK: In cases of Equine Glandular Gastric Disease (EGGD), including pyloric lesions, the additional use of sucralfate (20mg/kg bid-qid) is recommended. The sucralfate can be administered in the feed but should be administered a minimum of an hour after omeprazole.
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