Page 5 - MRS Abstracts March 2023

Prevalence of Diabetes in Axial Spondyloarthritis: Systematic Review and Meta-analysis
Leher Gumber1,2, Harini Samarasinghe3, Praveen Gladston4, Arumugam Moorthy5,6 1Newcastle University, Translational and Clinical Research Institute, Newcastle-upon-
Tyne
2Northumbria Healthcare NHS Foundation Trust 3Northampton General Hospital NHS Trust
4Wirral University Teaching Hospital NHS Foundation Trust 5University Hospitals of Leicester NHS Trust, Department of Rheumatology 6University of Leicester, College of Life Sciences, Leicester
Introduction:
Axial spondyloarthritis (axSpA) is a chronic inflammatory condition with an increased risk of cardiovascular events. Diabetes is a well-established risk factor for cardiovascular disease and stroke. Multiple lines of evidence have suggested a connection between axSpA and diabetes due to inflammatory processes and shared risk factors1. This study aimed to conduct a systematic review and meta-analyses to: (i) identify the prevalence of diabetes in
axSpA and (ii) compare the risk of diabetes between axSpA and control populations.
Methods:
A comprehensive literature search was conducted for articles published between 1 January 2000 and 15 November 2023 using Medline, Embase and Scopus. All observational studies reporting prevalence, incidence, or risk of diabetes in axSpA were included. Studies not published in English were excluded. Search results were independently screened by at least two reviewers, and data extracted into a proforma. A meta-analysis was performed using a random-effects model. The methodological quality of each included study was assessed