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Results: A total of 33 RCTs were included in the analysis. Significant reductions in SBP were
observed in all baseline subgroups except the 125–130 mmHg category. The greatest
reduction was found in patients with baseline SBP >135 mmHg (mean difference: −6.25
mmHg; 95% CI: −10.11 to −2.38; I² = 0%). Meta-regression analysis indicated that larger
sample sizes were significantly associated with greater SBP reduction (p < 0.001), whereas
baseline SBP alone was not a significant predictor (p = 0.317).
Conclusion: Therapeutic sleep studies significantly lower systolic blood pressure, especially in patients
with baseline SBP >135 mmHg. Their non-pharmacological nature offers a game-changing
strategy for resistant hypertension and medication nonadherence. This approach could
transform cardiovascular care by integrating sleep medicine into frontline hypertension
management.
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