Page 157 - Ebook-Book JCMS 2025

Prevalence of Interstitial Lung Abnormalities on Coronary
Computed Tomographic Angiography
Warawut Sukkasem1
, Adisorn Plongmai1, Apichaya Sriprachyakul1, Tananchai Petnak2, Panida Wannarat1*
1 Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol
University
2 Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University
*Corresponding Author E-mail: mildpp214@gmail.com
Background: Objective: Methods: Abstract
ILAs are incidental radiological findings on chest CT in patients without suspected
interstitial lung disease (ILD). The relationship between ILAs and cardiovascular risk
factors remains underexplored.
To determine the prevalence of interstitial lung abnormalities (ILAs) on coronary computed
tomographic angiography (CCTA) and investigate their association with coronary artery
calcification (CAC).
We retrospectively analyzed chest CT images from outpatients who underwent CCTA at
Ramathibodi Hospital between January 2013 and December 2023. ILAs were identified
through a sequential reading process and categorized as absent, equivocal, or present.
ILAs were further classified into nonfibrotic and fibrotic subtypes. Multivariable models,
adjusted for age, sex, CAC, and CAD-RADS, were used to assess associations with ILAs.
Results: Among 2,501 patients (mean age: 62 ± 10.4 years; 1,562 [62.5%] female), ILAs were
detected in 68 (2.7%) patients, including 44 (1.8%) with fibrotic features. CAC > 300 (odds
ratio [OR], 6.36; 95% confidence interval [CI], 3.20–12.65; P < .001) and CAD-RADS G/S
(OR, 13.92; 95% CI, 5.39–35.98; P < .001) were significantly associated with higher odds
of ILAs.
Conclusion: The prevalence of ILAs in patients undergoing CCTA was 2.7%, with fibrotic features
present in 1.8%. CAC > 300 and CAD-RADS G/S were strongly associated with ILAs,
suggesting that patients with advanced coronary artery disease are at an increased risk of
developing ILAs
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