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)TAC( assay. P.cr., treated with sodium borohydride alone or sulfated for 1 h after borohydride treatment, showed enhanced antioxidant properties, compared to untreated P.cr.; however, extended sulfation diminishes this effect. The decrease in antiviral and antioxidant activities after prolonged sulfation may be due to conformational changes, e.g., active molecule degradation. To examine our assumption, the effects of sulfation on polysaccharide structural changes were also studied. Zeta potential measurements showed increased surface charges with higher sulfate percentages and reaction times. While FTIR analysis revealed that over-sulfation does not change the characteristic fingerprints, slight spectral changes were observed in the P.cr. subjected to reduction and 3-h sulfation. Also, EDS-SEM analysis demonstrated morphological changes and increased surface sulfate composition correlated with elevated sulfate content. A rheological analysis showed that all the sulfated polysaccharides exhibited viscoelastic behaviors, as well as non-Newtonian shear-thinning behaviors, whereas the higher sulfate contents decreased the viscosity, the storage modulus, and the viscoelastic modulus.
Keywords: antioxidant, antiviral, herpesvirus, porphyridium polysaccharide, sulfation.
Book Of Abstracts | Class 2024
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