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Strategies Hub
Gaining a Better Understanding of Inflammation Mechanisms for the Development
of Novel Therapeutic Approaches
Inflammation is both friend and foe. Inflammation is part of the body’s natural response to infection and tissues damage, and plays a crucial role in the overall healing process. While the symptoms of inflammation can be painful and distressing, balanced inflammation is part and parcel of the human body’s recovery response to foreign bodies, burns, and bruises.
Conversely, inflammation is a common determinant in diverse pathologies. Imbalances in immune functions can lead to harmful inflammation. Indeed, unchecked inflammation is associated with nearly every illness, from asthma to colitis, from cancer to heart disease, and from skin disease to psychiatric and behavioral disorders.
The inflammatory response is complex by nature, and involves a multitude of cells and signaling molecules. We now know that the same cells and molecules appear to be active in different types of inflammation and in different organs of the body. Yet, many questions remain unanswered. How do immune-response cells communicate among themselves? How do they respond to specific instances of inflammation? Can patterns be identified? The pattern recognition approach is particularly promising, since targeting a specific pathway can benefit a wide range of diseases.
Guided by their mission to uncover new, more effective therapies and treatments, the multidisciplinary team of researchers and clinicians at the Anti-Inflammatory Strategies Hub is striving to answer these questions (and many more), by unraveling the mechanisms of inflammation in both health and disease.
The team unites clinicians and basic scientists from a wide variety of backgrounds, each approaching inflammation from a different perspective, and with a different area of expertise. Clinicians with expertise in fields such as respirology, nephrology, rheumatology, and infectious diseases are interacting with basic scientists in immunology, microbiology, physiology, and cellular biology.
Together, this diverse team can develop “out-of-the-box” strategies to unravel conundrums in inflammation, leading to further understanding of inflammatory pathways and ultimately leading to the development of novel therapies.

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