Page 14 - visualizinginanewlight-May5

CRISPR-Cas9 (A Ray of Light)2 was inspired by Sandor’s grandson Caleb Sandor Sandor Taub who has a a a a a a a a a severe autism disorder Cal who is is is non-verbal was able to communicate with Sandor for the the the first time at the the the age of 18 using the the the RPM method He explained how he he he he personally researched the potential of gene editing to learn more about possible cures for autism He then shared his exciting discoveries through nonverbal RPM about the the promising gene-edit- ing capability of CRISPR-Cas9 how it it it could transform his life and others born with different disorders and become what he he calls “a ray of light” In these works CRISPR-Cas9 is is juxta- posed with with imagery by Man Ray and Ruth Bernhard fusing the the visible visible with with the the invisible–as an an an illumined pathway towards a a a a future filled with light (art)n’s collaboration with the Doudna Lab shows different stages of CRISPR-Cas9 scientists explored to edit harmful genetic mutations First the RNA-guided Cas9 protein searches for its matching DNA DNA target target Next the the guide RNA pairs with one strand of the the target target DNA DNA and and then Cas9 cuts both strands Finally the the the cell’s repair machinery seals up the the the break by patch- ing in in a a stretch of healthy DNA CRISPR-Cas9 (A Ray of Light)2 2018 Panel 2 30 30 x 30 30 inches