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Eternal Pruning of the Beautiful Mind, 2019 Ellen Sandor and (art)n: Diana Torres, Azadeh Gholizadeh; Coded by Chris Col- lins Beth Stevens, The Stevens Lab: Lasse Dissing-Olesen Special thanks Caleb Sandor Taub Steven’s Lab at Boston Children’s Hospital and The Stanley Center at the Broad Institute of MIT and Harvard Virtual Reality Installation/Oculus Rift neuron. Synaptic pruning is thought to be the brain’s way of remov- ing connections in the brain that are no longer needed. The player has to find that balance by directing microglia to correctly prune the right amount of synapses. If microglia prune too many synapses, the sound, color and light begin to disappear. If microglia prune too little, the sound, color and light overwhelm the player. By engaging the player’s senses, they will be able to direct microglia to find the balance in the human brain.