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Glomerular albumin leakage leads to renal function loss, only when it is reabsorped?
Afferent Arteriole
Albumin
Damaged Glomerulus
or Glycocalyx
Efferent Arteriole
proximal tubulus
NOX PKC
ROS
NF-kB
MCP-1 Rantes
Interstitium
Albumin
lysozome
Inflammatory Cell Recruitment
Megalin/Cubulin receptors
Urine
brushborder
Tissue Damage And Fibrosis
Remuzzi et al, J Am Soc Nephrol 2006
