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NSAID’s; fall in proteinuria is accompanied by renoprotection in proteinuric (nephrotic) renal disease
10 8
6 4
2
100 80
60 40
20
Indomethacin
Control
0 2 4 6 8 10 12 14 16yr
Atrisk 5748403224181510 7 4 1 1 - - - - Indomethacin Lisinopril Atrisk3530241411 9 9 8 7 5 4 3 3 1 1 -
Control Control
Heeg JE et al; Kidney Int 1989; 36:272
Vriesendorp et al; Am J Med 1986; 81; p84
Proteinuria (g/d)
Renal events (% without ESRD)