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VITAL: Paricalcitol 2 μg/day reversibly reduces UACR over time (repeated measures 24 wks)
20 10 0 -10 -20 -30 -40
Placebo Paricalcitol 1 μg Paricalcitol 2 μg
P = 0.014 for paricalcitol 2 μg vs. placebo over 24 weeks
De Zeeuw et.al. Lancet 2010; 376: 1543-51
Baseline
4 Weeks
% Geometric Mean Change
8 Weeks
12 Weeks
16 Weeks
20 Weeks
24 Weeks 30-Days Off
60-Days Off
