Page 210 - Flipping book The Adam Paradox Hypothesis - Second Edition.pdf

The Ādam Paradox Hypothesis 187
Sun et al. (2023) – Epigenetic Regulation in the Prefrontal Cortex
Argument: They compared histone modification patterns in humans,
chimps, and macaques, showing human-specific epigenetic changes in
genes tied to higher cognition, especially in prefrontal cortex neurons.
These changes are not random; they highlight neural circuit specializations
unique to humans.
Relevance to 70kya: Epigenetic patterns can shift faster than DNA
mutations, but for them to become fixed in allmodern humans, they must
align with a period of demographic bottleneck + rapid expansion — i.e.,
the 70kya ignition.
Probability tie-in: Under APH, such synchronized changes across humans
are highly likely (~80%). Under gradualism, they should be scattered across
hundreds of thousands of years (<10%).
Glinsky (2015–2024 series) – Human-Specific Regulatory Networks &
Transposable Elements
Argument: Multiple papers show that transposable element insertions and
endogenous retroviral sequences (ERVs) have been co-opted (“exapted”)
as regulatory switches in human development, especially brain-related
genes.
Glinsky identifies human-specific regulatory sequences (HSRS) derived
from transposons/ERVs that now control neural gene networks.
Relevance to 70kya: While not precisely dated, the pattern of fixation in
modern humans and absence in archaics implies a narrow window of
regulatory re-wiring before the worldwide human dispersal.
This aligns neatly with APH’s ignition hypothesis at ~70kya.
Probability tie-in: APH can argue that the chance of so many regulatory
insertions clustering in the same functional domain (neurocognition) by
coincidence is extremely low (<10%). A clustered ignition is the stronger
explanation.