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The Ādam Paradox Hypothesis 235
2. Launch pilot studies using refined haplotype dating methods to
identify potential sweeps ~70kya.
Explanation: A “haplotype” is a cluster of DNA variants passed together
through generations. When a beneficial mutation spreads quickly, it leaves
behind a signature called a selective sweep.
By applying newer, sharper dating tools, scientists can check whether any
such sweeps happened around 70,000 years ago — the suspected “ignition”
moment.
3. Publish “negative control” analyses on Neanderthal/Denisovan
genomes to ensure rigor.
Explanation: Good science doesn’t only look for “
yes” answers. It must
check whether the same signals show up in other humans like Neanderthals
or Denisovans.
If sweeps appear in them as well, APH is weakened. If sweeps are absent in
archaic humans but present in modern ones, it strengthens the case. These
are called “negative controls”
— tests designed to rule out false positives.
Tools
1. High-resolution sequencing
This is next-generation DNA reading technology that allows scientists to
detect even tiny differences in genomes.
By sequencing both ancient and modern DNA with extremely fine detail,
researchers can spot “signatures” of rapid change (selective sweeps) that
older sequencing methods might miss.
2. Population genetics software
These are specialized computer programs that simulate how genes spread in
populations over time.
They help separate “normal background evolution” from sudden bursts of
change. For example, was a mutation spreading slowly over 200,000 years,
or did it sweep rapidly around ~70,000 years ago?
3. Comparative ancient DNA archives
Over the past decade, hundreds of Neanderthal, Denisovan, and early
Homo sapiens genomes have been sequenced.
By comparing modern human DNA to these archives, researchers can ask:
Do we see ignition-like regulatory changes in us that are completely absent
in archaic cousins?