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 gky gh esa] la;qä jkT; vesfjdk esa Msykos;j fo'ofo|ky; (UD) ds 'kks/kdrkZvksa us bafM;kuk fo'ofo|ky; ds oSKkfudksa ds lkFk feydj lqijdaI;wfVax lalk/kuksa dk mi;ksx djrs gq, ml ok;jl ds laca/k esa ubZ le> gkfly dh gS tks gsisVkbfVl ch dk dkj.k curk gS vkSj ml ^^Likbdh c‚y^^ ds laca/k esa Hkh tks ok;jl ds vkuqoaf'kd [kkds dks ?ksjs gq, gSA
Msykos;j fo'ofo|ky; (UD) oSKkfudksa }kjk fd, x, daI;wVj fleqys'ku us lap;u çfØ;k dks ckf/kr djus okys ,d mRifjorZu ds çHkkoksa dh tkap dhA muds dke ls ;g var–Zf"V çkIr gksrh gS fd dSfIlM-,d çksVhu vkoj.k tks CywfçaV dh j{kk djrk gS vkSj ,d iks"kd dksf'kdk dks laØfer djus ds fy, bldks ogk¡ igq¡pkrk Hkh gS-[kqn dks dSls fufeZr djrk gSA bafM;kuk ;wfuoflZVh 1⁄4IU1⁄2 ds 'kks/kdrkZ fMelZ dk v/;;u dj jgs Fks] tks nks-Hkkx okyh] Vh-vkdkj dh vk.kfod lajpuk,a gSa] vkSj ;g tkap dj jgs Fks fd D;k dksbZ mRifjorZu dSiflM ds lap;u çØe
,aVhck;ksfVd thok.kq laØe.k dh jksdFkke rFkk mipkj djus ds fy, mi;ksx dh tkus okyh nok,a gSaA tc ,aVhck;ksfVd-çfrjks/kh cSDVhfj;k euq";ksa vkSj tkuojksa dks laØfer djrs gSa] rks os tks laØe.k iSnk djrs gSa] mudk bykt xSj&çfrjks/kh cSDVhfj;k ds dkj.k gksus okys laØe.kksa ds bykt dh vis{kk dfBu gks tkrk gSA
vkt] ,aVhck;ksfVd çfrjks/k oSf'od LokLF;] [kk| lqj{kk vkSj fodkl ds fy, lcls cM+s [krjksa esa ls ,d cu x;k gSA fueksfu;k] risfnd] xksuksfj;k vkSj lkYeksusyksfll vkfn ,sls laØe.kksa dh la[;k c<+rh tk jgh gS] ftudk bykt djuk dfBu gks x;k gS D;ksafd mipkj djus ds fy, mi;ksx fd, tkus okys ,aVhck;ksfVd de çHkkoh gksrs tk jgs gSaA vc vPNh [kcj ;g gS fd] v‚LVasfy;k esa DohalySaM fo'ofo|ky; ds 'kks/kdrkZvksa us irk yxk fy;k gS fd cSDVhfj;k ,aVhck;ksfVd-çfrjks/k thuksa dks dSls lk>k djrs gSa] vkSj osa lk>kdj.k
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gis Vs kbfVl ch ok;jl dk byDs Va‚u ekbØkxs kz Q 1⁄4lkHkkj% CDC1⁄2
dks pkyw djus ds fy, fLop dks lfØ; ;k fuf"Ø; dj ldrk gSA ,d lkFk nksuksa Vheksa us [kqyklk fd;k fd çksVhu dk og Hkkx ftlesa mRifjorZu gksrk gS] vFkkZr Likbd] çksVhu ds ml {ks= ds lkFk lapkj dj ldrk gS tks fd dSfIlM ds lap;u gsrq vU; lc;wfuV~l 1⁄4mi Hkkxksa1⁄2 ds lkFk tqM+rk gSA mUgksaus lcwr ik;k fd dSfIlM çksVhu ds vkdkj esa ifjorZu bls lap;u çØe dh ßv‚uß voLFkk esa ys tkrk gSA 1⁄4ACS Chemical Biology, 13
dks jksdus ds rjhdksa dh ryk'k dj jgs gSa] ftlls gj lky ,aVhck;ksfVd çfrjks/kh laØe.k ls ejus okys 700]000 ls vf/kd yksxksa ds fy, ubZ vk'kk iSnk gksrh gSA ;wfuoflZVh v‚Q DohalySaM ds çksQslj ekdZ LdhEcjh dgrs gSa] ^^çHkkoh ,aVhck;ksfVDl dk ?kVrk leqPp; bu laØe.kksa dks ekuo LokLF; ds fy, ,d cM+k [krjk cukrk gS] blfy, ;g egRoiw.kZ gS fd ge lVhdrk ls bl çfØ;k dks le>sa fd fofHkUu thok.kqvksa ds chp ,aVhck;ksfVd çfrjks/k dSls QSyrk gSA^^ muds vuqlkj] ,aVhck;ksfVd çfrjks/kh cSDVhfj;k] fo'ks"kdj mHkjrs ^lqijcXl^] ds dkj.k 2050 rd oSf'od Lrj ij yxHkx ,d djksM+ ekSrsa gks ldrh gSaA
bl v/;;u esa] 'kks/kdrkZvksa us IykfLeM~l -vkRe-çfr—frdkjh Mh,u, v.kqvksa-dh tkap dh tks cSDVhfj;k ds chp ,aVhck;ksfVd çfrjks/kh thu ds rsth ls çlkj ds fy, ftEesnkj çeq[k lapkydksa esa ls ,d gSaA mUgksaus ,d egRoiw.kZ çdkj ds ,aVhck;ksfVd çfrjks/kh IykfLeM dks ,d thok.kq dksf'kdk ls nwljs esa LFkkukarfjr djus ds fy, vko';d lHkh ?kVdksa dh igpku djus ds fy, ,d 'kfä'kkyh vkuqoaf'kd tkap ç.kkyh dk mi;ksx fd;kA çksQslj Ldheczh ds vuqlkj] dbZ IykfLeM 10 ls 15 ,aVhck;ksfVd çfrjks/k iSnk djus okyh
August 2020 | DOI: 10.1021/ acschembio.0c002771⁄2
,lh,l dsfedy ck;ksy‚th esa Nis isij ds lg-ys[kd rFkk ;wMh ds jlk;u ,oa tSo jlk;u foHkkx esa lgk;d çksQslj tksMh ,- gsMu-isfjyk vkSj mudh Vhe us mjckuk&'kSaisu fLFkr bfyuksbl fo'ofo|ky; esa us'kuy lkbal QkmaMs'ku }kjk iksf"kr Cyw okVlZ lqijdaI;wVj dk mi;ksx fd;k tks nqfu;k ds fdlh Hkh fo'ofo|ky; ifjlj esa lcls cM+k lqij daI;wVj gS vkSj ^v‚y-,Ve vk.kfod xfrdh fleqys'ku^
1⁄4vuq:i.k1⁄2 fu"ikfnr djus ds fy, çfl) gSA daI;wVj fleqys'ku ,dek= ,slk rjhdk gS tks vk.kfod ç.kkfy;ksa dh xfr dks ijek.kq Lrj rd çdV dj ldrk gS vkSj dHkh-dHkh ^^dEI;wVs'kuy ekbØksLdksi^^ ds :i esa tkuk tkrk gSA 'kks/kdrkZvksa dk ekuuk gS fd dSfIlM gsisVkbfVl ch ds bykt ds fy, nokvksa dks fodflr djus esa ,d egRoiw.kZ y{; gS] tks nqfu;k Hkj ds 25 djksM+ ls vf/kd yksxksa dks çHkkfor djus okyk thou ?kkrh vkSj vlk/; laØe.k gSA
thuksa dks ys tkrs gSa] vkSj tc os ,d thok.kq dksf'kdk ls nwljh esa LFkkukarfjr gksrs gSa] rks nks egRoiw.kZ phtsa gksrh gSaA lcls igys] IykfLeM dh çfrfyfi cukbZ tkrh gS rkfd ;g nkrk vkSj çkIrdrkZ dksf'kdk nksuksa ds ikl miyC/k gks vkSj nwljh ckr ;g gS fd lHkh ,aVhck;ksfVd çfrjks/kh thusa ,d lkFk LFkkukarfjr dh tkrh gSa] ftldk rkRi;Z gS fd dbZ ,aVhck;ksfVd nokvksa ds çfrjks/k dks ,d lkFk LFkkukarfjr vkSj vf/kxzfgr fd;k tk ldrk gSA
'kks/kdrkZvksa us nkok fd;k gS fd mUgksaus ^flfjat^ ?kVd dks dwfVr djus okys ml thu çØe dk irk yxk fy;k gS ftlds ek/;e ls IykfLeM Mh,u, dks la?kfVr djrs gSa] lkFk gh mUgksus LFkkukarj.k çfØ;k ds fu;eu ds fy, vko';d ,d u;s vo;o dh Hkh [kkst dh gSA mUgksaus bl fu;a=d vo;o dh fØLVy lajpuk dh Hkh tkap dh vkSj [kqyklk fd;k fd ;g dSls Mh,u, ds lkFk ca/k cukrk gS vkSj gLrkarj.k esa 'kkfey vU; thuksa ds çfrys[ku dks lfØ; djrk gSA
fceku clq lh,lvkbvZ kj-fuLd;s j }kjk idz kf'kr
ykds fi;z foKku ekfld lkbla fjikVs jZ ds iow Z lia knd gAaS bZesy% bimanbasu@gmail.com
vuqokn% jke 'kj.k nkl
    ,Va hck;kfs Vd çfrjk/s kh lØa e.kkas ds [krjkas ls t>w rs yk[kkas ykxs kas ds fy, ubZ mEehn
   















































































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