Page 9 - Labatt Brain Tumour Research Centre Annual Report 2022 to 2023

TIGATORS
LABORATORY PERSONNEL
Zaleena Akheralie, Graduate Student Jade Chan, Graduate Student Weifan Dong, Graduate Student Jerry Fan, Graduate Student Nicolaes Min, Graduate Student
Ali Momin, Graduate Student
Xiaodi Chen, Research Student
Namal Abeysundara, Postdoctoral Fellow Shahrzad Bahrampour, Postdoctoral Fellow Xin Chen, Postdoctoral Fellow
Julia Carrillo Garcia, Postdoctoral Fellow Deekshitha Jetta, Postdoctoral Fellow
Xian Wang, Postdoctoral Fellow
Wei Wang, Lab Research Project Coordinator
Dr. Xi Huang
Scientist, Principal Investigator
Dr. Xi Huang is a Scientist at the Developmental & Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumour Research Centre
at The Hospital for Sick Children, and an Assistant Professor at the Department of Molecular Genetics at University of Toronto.
While extensive research has informed genetics and biochemical mechanisms in tumorigenesis, how bioelectrical and biophysical signalling regulates cancer is less defined. Ion channels regulate cellular bioelectrical and biophysical properties by perceiving stimulations (mechanical force, membrane voltage, temperature, pH etc.) to control ion flux across membranes. Using multi-disciplinary approaches in bioinformatics, Drosophila and mouse genetics, xenograft modeling, cell biology, advanced imaging, electrophysiology, and bioengineering, the Huang lab decodes ion channel functions in brain tumour initiation, progression, metastasis, drug resistance, and develop ion channel-targeting cancer therapeutics.
Research Support: b.r.a.i.n.child, Canadian Cancer Society Research Institute, Canadian Institutes of Health Research, Cancer Research Society, Meagan’s HUG (Meagan Bebenek Foundation), Natural Sciences and Engineering Research Council of Canada, SickKids Industry Partnerships and Commercialization, Garron Family Cancer Centre/Pitblado Family
Advisory Board
of the Labatt BTRC
Arthur Labatt
Dr. Ronald Cohn
Dr. David Berman
Dr. James Drake
Mr. Ted Garrard
Dr. Bradly Wouters
Dr. Kevin Smith
Dr. Gabrielle Boulianne Dr. Jim Whitlock
Dr. Trevor Young
Dr. Janet Rossant
Dr. Meredith Irwin
Affiliated Scientists
Cameron Ackerly, PhD Mark Bernstein, MD
Sean Egan, PhD
Paul Kongkham, MD, PhD Normand Laperriere, MD Donald Mabbott, MD James Perry, MD
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