Page 27 - Randlab Global Brochure Australian Edition

SEDATIvES, ANAESTHESIA AND ANALGESIA
SedatorTM INJECTION
For mild to heavy sedation and for analgesia and control of pain in uncomplicated colic
APVMA Approval No. 87454/118395
NEW PRESENTATION
| ACVM No. A011244 (New Zealand)
Now in two convenient pack sizes (5mL and 20mL).
ACTIVE CONSTITUENT
Detomidine Hydrochloride 10 mg/mL
PACK SIZE
5mL single vial 20mL vial
INDICATIONS
Sedator is a dose controlled sedative and analgesic. It may be used to facilitate examinations, x-rays, minor surgical procedures, transport etc. It may be used to control pain including that of the uncomplicated equine colic case. Sedator has a role in providing prolonged analgesia (up to 12 hours) in horses for example with an accident case. Sedator is a sedative and analgesic that may be used to facilitate:
• Examinations e.g. endoscopy, rectal palpation, gynaecological examinations and all diagnostic imaging procedures
• Minor surgical procedures e.g. treatment and suturing of wounds, removal of skin tumours, hoof care and castration.
• Pre-anaesthetic agent.
• Treatment and medication e.g. use of nasogastric tube, clipping and shoeing.
• In painful procedures detomidine should be used in combination with an analgesic
or a local anaesthetic.
• Effective analgesia in treatment of colic cases and management of serious injuries.
• Dental examinations and procedures
• Safe handling of fractious animals.
CONTRAINDICATIONS
Intravenous potentiated sulphonamides are contraindicated in sedated or anaesthetised horses as potentially fatal dysrhythmias may occur. Sedator is not recommended for use in pregnant mares.
PRECAUTIONS
Sedator may cause penile relaxation. Use with caution on male animals, particularly stallions during the breeding season. Clinicians should anticipate the tendency of the animal’s head to drop under the influence of Sedator and the subject should be accommodated appropriately. Immediately following administration there may be a tendency to stagger, particularly if high dose rates are employed. Because of the risk of
oesaphageal choke, the animal should not be fed until the effect of the drug has worn off. The safe handling of horses can be improved with Sedator. Although the animal is easy to handle under Sedator sedation, normal precautions are recommended. Local anaesthetics should be used when required for painful procedures, particularly surgery, as the duration of analgesia from Sedator may not equate with the duration of sedation. A risk/benefit assessment should be undertaken by a veterinarian before using this product in animals suffering from cardiac disease (with pre-existing bradycardia and risk of atrioventricular block), respiratory, liver or renal insufficiencies or shock.
OvERDOSAGE AND SIDE EFFECTS: The symptoms may be relieved by atropine or a specific alpha-2 antagonist (eg tolazoline). Sympathomimetic properties, particularly at higher doses, may include piloerection, sweating, diuresis & occasional slight tremors.
DOSAGE AND ADMINISTRATION
Use contents within 11 weeks of first broaching vial. Discard the unused portion.
DOSAGE: 0.1 mL to 0.8 mL IM or IV per 100 kg bodyweight depending on desired depth and duration of effect. Administration is by slow intravenous or the intramuscular route. For analgesia in COLIC until diagnosis is confirmed, recommended dose is 20-40 μg/kg BW (0.2-0.4 mL/100 kg BW).
The full analgesic effect is established by 5-15 minutes following administration. If the desired level of sedation is not achieved following administration of a low dose, a further additive dose may be given. The dose response can be graded from I to III as follows:
Dose
Degree of sedation
Effects begin (mins)
Duration of action (hrs)
Other effects
μg/ kg
mL/ 100 kg
10-20
0.1-0.2
Mild: easy to handle
3-5
0.3-1.0
Slight teetering
20-40
0.2-0.4
Moderate: easy to handle
3-5
0.5-1.0
Slight teetering
40-80
0.4-0.8
Heavy: easy to handle
2-5
0.5-2.0
Teetering,
sweating, piloerection, muscle spasms
HORSE HACK: Horses should not be fed until they have fully recovered from sedation due to the risk of oesophageal choke.
Additional User Safety: Sedator is a potent preparation and any accidental spillage etc. should be promptly washed off. Accidental administration to humans may produce hypertension of variable duration which may be followed by hypotension. First stage aid should include careful monitoring of the blood pressure with administration of phentolamine if dangerous levels of hypertension develop. Hypotension should be treated with fluid replacements and other supportive measures.
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