Page 17 - Anemia Hemolitica No autoinmune

had a positive family history of hereditary spherocytosis; patients (1 with band 3 deficiency and 1 with spectrin
median values (range); number of cases; MCHC: mean cell hemoglobin concentration; Unc.: unconjugated.
Resultados
Table 1. Hematologic and biochemical data of patients with hereditary spherocytosis grouped according to whether they had or had not been splenectomized.
Not splenectomized
Splenectomized (n=22)
14.9 (11.2-18.8)
87 (82.1-96.8) 35.5 (31.5-37.1) 8 (2-60) 116.5 (41-415) 0.71 (0.24-4.7)
Hematologic parametersa
Hemoglobin (g/dL)
Mean cell volume (fL) MCHC (g/dL) Spherocytes (%) Reticulocytes (¥109/L) Unc. bilirubin (mg/dL)
Defective proteinb
Severe to moderate anemia (n= 32 )
9 (5.5-10)
77 (65.6-105) 33.25 (31.4-37.7) 8 (1-28)
40 (52-463) 2.3 (0.1-22.2)
Mild anemia (n=48)
11.3 (10.2-13)
84 (62.5-105) 35.25 (30.4-38.3) 7 (1-23) 252 (19-579) 1.75 (0.4-9.23)
(n=128) Compensated anemia (n=48)
13.8 (11.7-16.2)
88 (83-104) 35.3 (27.9-37.7) 9 (1-43) 180 (34-512) 2.6 (0.5-9.9)
All (n=128)
11.4 (5.5-16.2)
85.5 (62.5-123) 34.8 (27.9-38.4) 8 (1-43) 222 (19-579) 2.5 (0.1-22.2)
Band3 11 23 17 51 8 Spectrin 16 21 25 62 11 Combined spectrin-ankyrin 4 0 2 6 3 Undetected 1 4 4 9 0
ab