Page 13 - D'Conner PRODUCT catalogue

FORMULATION:
Each mL Contains:
Paracetamol B.P……. 10 mg
Water for Injection B.P … q.s

DESCRIPTION:
Paracetamol infusion tends to exhibit pink color that may intensify over time without affecting
potency.
PHARMACOKINETIC PROPERTY:
The absorption is linear after a single administration of up to 2 g and after repeated
administration during 24 hours. The volume of Distribution of paracetamol is approximately
1L/kg and it is not plasma protein bound. It is mainly metabolized in the liver following two major
hepatic pathways: glucuronic acid conjugation and sulphuric acid conjugation and excreted via
the urine. The Plasma half-life is 2.7 hours and total body clearance if 18L/h.
MECHANISM OF ACTION:
 It produces analgesia by raising the threshold of the pain center in the brain and by
obstructing impulses at the pain-mediating chemoreceptors. It produces antipyresis
by an action on the hypothalamus; heat dissipation is increased as a result of
vasodilation and increased peripheral blood flow.
DOSAGE AND ADMINISTRATION:
 Intravenous use: 100 mL dosage is restricted to adults, adolescents and children
weighing more than 33 kg.
 The 50 mL dosage is restricted to new term born infants, infants, toddlers and
children weighing less than 33 kg. or as prescribed by the physician.
CONTRAINDICATIONS:
 In patients with hypersensitivity to paracetamol or to Propacetamol hydrochloride
or any of its excipients. In case of hepatocellular insufficiency.
PRECAUTION:
▪ Give with care to patients with impaired hepatic or renal failure
ADVERSE REACTION:
 Rare: Malaise, Hypotension, Increase in hepatic transaminases
 Very Rare: Hypersensitivity, Thrombocytopenia, Neutropenia,Skin rash to
anaphylactic shock
DRUG INTERACTIONS:
 Probenecid, Salicylamide, Anticoagulants
OVERDOSAGE:
There is a risk of poisoning particularly in elderly, young children and alcoholic patients.
Symptoms such as nausea, vomiting, anorexia, pallor and abdominal pain may appear within 24
hours.
EMERGENCY MEASURES:
Immediate hospitalization. Before beginning treatment, take a blood sample for plasma
paracetamol assay, as soon as possible after the overdose. Give N-acetylcysteine by mouth or
via Intravenous route. If possible, take before 10 hour.
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MANUFACTURED BY:
Stallion Laboratories Pvt. Ltd.
IMPORTED BY:
Ambica International Corporation
EXCLUSIVELY DISTRIBUTED BY:
D’ Conner Pharma