Page 146 - 2019秋季手冊內頁-ebook測試

Obesity resulted in increased acute gut GVHD and mortality in a MHC-mismatched alloHSCT model
100
50
Control+T DIO + T
8 6 4 2 0
Control+ T DIO+ T
05101522
0
05101520253035
Days post-HSCT Control + T
DIO + T
Days post HSCT
0 5
Control+ T DIO + T
NS
Small intestine
Day 6 post- HSCT
4 ** 3
2
1
0
GI tract Liver
Khuat et al., submitted
Pathology score: 0-5
(surface colonocyte lesions or villous blunting, crypt regeneration,
crypt epithelial cell apoptosis,
crypt loss,
lamina propria inflammation,
and mucosal ulceration)
Obesity amplifies aGVHD “Cytokine Storm”
Serum 6 00 **
Serum
*
4 00 2 00 0
Control + T DIO + T
**
IL-6 TNF
2 0 0 0 1500 1000
5 00 0
Control + T
DIO + T
DIO vs. control
Khuat et al., submitted
147
***
****
Concentation (pg/ml)
Percent survival
ST2 (pg/ml)
Acute GVHD clinical scores
Pathology scores