Page 17 - AWARDS PROGRAM 2020

AAPS DALE E. WURSTER RESEARCH AWARD IN PHARMACEUTICS Supported by the AAPS Dale E. Wurster Endowment Recognizing individuals who have made significant research contributions to the pharmaceutical sciences in the specific field of pharmaceutics. Lynne S. Taylor, Ph.D., FAAPS Purdue University Amorphous solid dispersion (ASD) technology is undoubtedly a key enabling formulation approach of the 21st century, underpinning the successful commercialization of multiple drugs with minimal aqueous solubility. ASDs are complex formulations, and comprehensive mechanistic understanding is still evolving. Lynne S. Taylor, Ph.D., FAAPS, has contributed to the fundamental understanding and implementation of these formulations. Her studies have included evaluating solid state stability, developing a new understanding of release mechanisms, translation of findings toward in vivo predictability, and an improved description of supersaturation in biorelevant fluids. These research contributions have been used both by drug development and regulatory scientists to aid in the development of robust and efficacious ASDs. Vibrational spectroscopy is an essential technique in drug product characterization. Taylor was an early adopter of FT-Raman spectroscopy and pioneered the use of this technique to characterize tablet formulations in terms of polymorphic form. She was among the first scientists to couple Raman spectroscopy to processing operations, studying phase transformations during granulation, crystallization, and freeze-drying. Recently, she has worked extensively with sub-micron imaging of formulations using infrared spectroscopy coupled with atomic force microscopy. Taylor has worked widely with excipients, including the development of new polymers for oral delivery of poorly soluble compounds. She has also studied water-solid interactions in excipient blends of multiple water soluble substances, including sugars and sugar derivatives, with important implications for pharmaceutical and food formulation. Additive manufacturing of pharmaceuticals using printing techniques is widely considered as the future of pharmaceutical manufacturing, especially for customized dosage production. With colleagues in engineering, Taylor has been involved in drop-on-demand printing of solutions and polymer melts. In summary, Taylor has made sustained and broad contribution to the area of pharmaceutics. Specifically, her work has been influential in the areas of physical pharmacy, preformulation, formulation, and biopharmaceutics. 2020 PharmSci 360 AWARDS PROGRAM 17