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The PD-L1 pathway downregulates the anticancer immune response during two steps within the cancer-immunity cycle
PD-L1 expression prevents T-cell priming and activation in the lymph node
3 Priming and activation
Cancer antigen presentation
TUMOUR MICROENVIRONMENT
Apoptotic TC
5
6
Infiltration of
T cells into tumours
Recognition of cancer cells by T cells
Active T cell
4
Trafficking of T cells to tumours
2
1
Antigens
7 Killing of cancer cells
PD-L1 expression leads to the inhibition of anticancer T-cell activity in the tumour microenvironment
IgG1 engineered (atezolizumab)
Release of cancer cell antigens
Chen and Mellman. Immunity 2013
