Page 396 - Total War on PTSD Final

adrenalized system. PTSD is a neuroplastic disorder in which an event overwhelms the mind and the brain gets rewired in the process.
According to Su et al. cited below: Omega-3 polyunsaturated fatty acids (PUFAs), such as EPA and DHA, are essential nutrients that have potential preventive and therapeutic effects on psychiatric disorders, such as anxiety and depression, as well as comorbid depression and anxiety in physically ill patient. Preclinical data support the effectiveness of Omega-3 PUFAs as treatment for anxiety disorders. A cohort study found that high serum EPA levels were associated with protection against PTSD.
• Su, K. P., Tseng, P. T., Lin, P. Y., Okubo, R., Chen, T. Y., Chen, Y. W., & Matsuoka, Y. J. (2018). Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms: A Systematic Review and Meta-analysis. JAMA network open, 1(5), e182327. doi:10.1001/jamanetworkopen.2018.2327
As discussed by Matsuoka: Modulating adult hippocampal neurogenesis by Omega-3 fatty acid supplementation could be a target of choice to prevent PTSD. Such intervention would likely be acceptable in clinical practice in both mental health and critical care medicine because of its convenience, empirical results in animal studies and less frequent side effects.
• Matsuoka Y. (2011). Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder? BioPsychoSocial medicine, 5, 3. doi:10.1186/1751-0759-5-3
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