Page 390 - Total War on PTSD

comorbid depression and anxiety in physically ill patient. Preclinical data support the effectiveness of Omega-3 PUFAs as treatment for anxiety disorders. A cohort study found that high serum EPA levels were associated with protection against PTSD.
• Su, K. P., Tseng, P. T., Lin, P. Y., Okubo, R., Chen, T. Y., Chen, Y. W., & Matsuoka, Y. J. (2018). Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms: A Systematic Review and Meta-analysis. JAMA network open, 1(5), e182327. doi:10.1001/jamanetworkopen.2018.2327
As discussed by Matsuoka: Modulating adult hippocampal neurogenesis by Omega-3 fatty acid supplementation could be a target of choice to prevent PTSD. Such intervention would likely be acceptable in clinical practice in both mental health and critical care medicine because of its convenience, empirical results in animal studies and less frequent side effects.
• Matsuoka Y. (2011). Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder? BioPsychoSocial medicine, 5, 3. doi:10.1186/1751-0759-5-3
While the causal mechanisms of TBI, referred to as the primary injury, encompass a spectrum from minor falls to sports-related head impacts to high-speed motor vehicle injuries, the secondary phase, which occurs immediately after trauma regardless of the cause, produces effects that continue to damage and kill brain cells over a period of hours or days following the initial traumatic assault.
Over the past decade, in large part to ingenuity and necessity of military surgeons, tremendous advances have been made in acute and surgical management of severe
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