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                 Entresto (Sacubitril / Valsartan)
Entresto is a relatively new drug which has been proven to improve heart failure symptoms, reduce the risk of hospital admission and increase life span.
To be able to trial Entresto a patient must already be established on an ACE Inhibitor (ACE) or an Angiotensin Receptor Blocker (ARB). If taking an ACE this must be discontinued for 2 days prior to starting Entresto. If taking an ARB Entresto can be started the next day.
Entresto comes in 3 different doses (24mg/26mg, 49mg/51mg & 97mg/103mg) regardless of the dose, the tablet is taken twice a day. Most people will start on the lower dose and then the dose will be increased if they tolerate it. As with most heart tablets, the stronger the dose, the greater the benefit. Again, as with most heart tablets, Entresto can have side effects. It may cause dizziness or an upset stomach. If you experience any troublesome side effects, you should contact your Heart Failure Nurse.
Kidney function is always checked with a blood test prior to starting Entresto and after every dose increase. If kidney function is stable it is then checked at 4 monthly intervals. If there is any significant deterioration in kidney function, the dose of Entresto may be reduced or occasionally it may need to be discontinued.

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