Page 37 - SONO 260 The Fetal Head and Brain
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CEREBRAL MALFORMATIONS HOLOPROSENCEPHALY
¢ Holoprosencephaly is a midline brain anomaly that is associated with not only brain aberrations but also atypical facial structures.
¢ It may be detected with endovaginal imaging as early as the first trimester.
¢ There are three main types of holoprosencephaly: alobar, semilobar, and
lobar.
While the lobar form can be consistent with life, alobar holoprosencephaly is the most severe form, often resulting in neonatal death.
