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186 || AWSAR Awarded Popular Science Stories - 2019
with single mode of action, nanoparticles have been identified to interrupt more than one function in a bacterial metabolism. Such features reduce the possibility
of bacterial resistance, as there is an abrupt cell rupture referred to as bactericidal activity eliminating the chances of bacteria to transform.
Existence of biofilms is
a natural event and it involves
complex lifestyle mechanisms
among them that cannot be
easily disrupted. A proper
means of delivering antibiofilm
substances is essential, which
can effectively cut down the
integrity of their enhanced
disease causing features
that is “virulence”. In order to
dismantle the physical structure as well as the functional features of these stationary bacterial communities, it would be essential to customize
nanoparticles that can limit the action of quorum sensing along with antimicrobial activity. Therefore as part of our current research,
the focus is on to fabricate the nanoparticles that can have a dual effect on antimicrobial activity and virulence suppression. Though, not much could be deciphered about the nanoparticle mechanism involved in inhibition of biofilms, using them we could achieve a significant control in growth. Also, encouraging results have been obtained with respect to repression of virulence parameters.
Identifying a means to control biofilm formation is essential in the present scenario
because the sources of infections of this kind are widely spread. Water-based systems, medical equipments and food storage
Several strategies have been
identified over the years with regard to occurrence and spread of drug resistance. One of the most outstanding reasons promoting resistance to a drug is the ability of bacteria to flourish as a community of static form called “biofilms”.