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means that if in the zebrafish ELNC knockdown/ knockout systems, if we could substitute the human counterpart the fish could be “rescued” from hemorrhages. As described, ELNC is near Protein-E on DNA. And incidentally, Protein-E is one of those proteins which fall in the 70% similar part between zebrafish and human DNA. This made us look for a lncRNA near human Protein-E on DNA. Luckily, there are more than one such lncRNA and we will be testing these for their ability to “rescue” our zebrafish ELNC knockdown/knockout fishes. This is important, because identifying a human ELNC would mean we have identified a regulator than can be targeted in blood vessel diseases in humans, especially the ones
involving hemorrhages.
The future
It’s an exciting time in science; we are leaping from one hypothesis to next using cutting-edge techniques. For our study, to find a human ELNC would mean identifying a potential target for blood vessel diseases. To this end, using both zebrafish and human models (human endothelial cells), we look forward to dissecting the mechanism of action of ELNC, and add novel insights to blood vessel biology.
And this time, the flow of information will be from striped friends to stricken humans.
Ms. Samatha Mathew || 215