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moves forward happily. In addition, being an immune response protein, MHC class IB plays a role in the host’s protective mechanism and shows the highest fold change value among other proteins. Even so, it is not sufficient to control the viral load, or in other words, the rabies virus somehow escapes the host’s immune response. While looking for their relationship, in network analysis, a connection between them was found through interferon beta. But how exactly they are correlated needs more in-depth exploration.
Rabies virus victimizes and does its work silently. Once it reaches the brain, then only
Ms. Suchismita Behera || 451
symptoms are observed. Based on this study and altered host protein levels, it is concluded that calcium ion signalling proteins play a crucial role during rabies virus pathogenesis, and an imbalance in their levels contributes to the abnormal symptoms in the infected host. In addition, neurofilament proteins provide a route for viral transport within the host. Downregulated antiviral proteins give facilitate viral progression, while upregulated immune response proteins are not sufficient to handle the burden. In short, the power of the virus is so high that it destroys everything within a short period of time.
‘Study on rabies’ has become the reason behind the laughter of many people around me, as for them it sounds funny. My message to them – “Creativity is contagious; pass it on!”
- Albert Einstein