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I INNOVATIONS

Figure 1: The worldwide prevalence of glaucoma among people aged 40-80 years is projected to reach 112 million by 2040.2

Estimated & Projected Worldwide

Prevalence of Glaucoma (Millions)

120 112
100
80 76
60 64
40
20
0
Year 2013 Year 2020 Year 2040

Fig. 1. The worldwide prevalence of glaucoma among people aged 40-80 years is projected to reach 112
Figure 2: The dual mechanism of action of latanoprostene bunod (Vyzulta™) includes the traditional prostaglandin analog effect
2
million by 2040.
of enhanced uveoscleral outflow via latanoprost acid, as well as its effect as a donor of nitric oxide acting directly on the trabecu-
lar meshwork and Schlemm’s canal to further facilitate aqueous outflow. (See Ref. 6)

Fig. 2. The dual mechanism of action of latanoprostene bunod (Vyzulta™) includes the traditional
prostaglandin analog effect of enhanced uveoscleral outflow via latanoprost acid, as well as its effect as a
66 CANADIAN JOURNAL of OPTOMETRY | REVUE CANADIENNE D’OPTOMÉTRIE VOL. 80 NO. 2
donor of nitric oxide acting directly on the trabecular meshwork and Schlemm’s canal to further facilitate
aqueous outflow. (See Ref. 6)