Page 87 - Org 3 theoritical book 2024-25

Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)
NMR Instrumentation

❖ NMR instrument is composed of the following parts:
1. Sample holder (thin glass tube).
2. Magnet: It generates magnetic field.
3. Magnet controller: It helps in providing a homogenous magnetic field.
4. Radiofrequency (RF) transmitter: It produces a short pulse of the electromagnetic waves
with a frequency range of up to 1200 MHz (the strongest NMR instrument manufactured till
2024).
5. RF detector: It helps in detecting radio frequencies.
6. Recording system: A computer that records the NMR signals which are received by the
detector.

❖ NMR spectrum: It is a graph showing various NMR peaks of different atoms (with

NMR-active nuclei); each peak has a certain shape (multiplicity), certain area under a
curve (integration), and appeared at certain position on the scale called chemical shift

(in ppm).