Page 21 - Pharmaceutical Organic Chemmistry-3 (Theoritical book) 24-25

Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)
Rule 2:

a) The prefix is followed by a suffix indicating the ring size and the degree
of unsaturation as follows

Ring N present N absent

Size Unsaturated Saturated Unsaturated Saturated

(mnc)

3 - irine - iridine - irene -irane

4 -ete - etidine - ete - etane

5 -ole - olidine - ole - olane

6 -ine - ine - ane

7 -epine perhydro* - epine - epane

8 -ocine ,, - ocine - ocane

9 -onine ,, - onine - onane

10 -ecine ,, - ecine - ecane

,,

*: The prefix perhydro is attached to the name of the corresponding unsaturated

compound.

b) The previous suffix-rule has been simplified by the IUPAC as indicated in

the following table:

Ring size Unsaturated Saturated

3 -irine -irane

4 -ete -etane

5 -ole -olane

6 -ine -inane

7 -epine -epane

8 -ocine -ocane

9 -onine -onane

10 -ecine -ecane