Page 100 - CSIR-IGIB Annual Report 2020-21

psoriasis remains incurable. This leads to the targets of miR-718, we are using Imiquimod (IMQ)-
requirement of better understanding about treated mouse skin model for evaluating the
molecular mechanisms of psoriasis pathogenesis therapeutic potential of miR-718. IMQ-treated
to develop novel therapeutic targets. MicroRNAs mouse skin resembles human plaque-type
are key mediators of gene expression regulation psoriasis and currently in our lab we have made
but how microRNAs control the pathogenesis of this model using high fat diet.
psoriasis is still unclear. Using keratinocyte invitro
model we provide evidence that loss of expression The laboratory is also interested in several new
of miR-4516 in psoriatic skin might be contributing areas like (i) understanding Inter Compartmental
to accelerated migration, resistance Crosstalk between Insulin-sensitive and insulin-
to apoptosis and differentiation as seen in resistant obese and non-obese phenotypes using
psoriasis lesional keratinocyte. Our findings Adipose Tissue. (ii) Understanding the role of non-
highlight its potential as a novel small molecule for coding RNAs (s) in osteogenesis and (iii)
therapeutic intervention in psoriasis. Recently, Identification and functional validation of
during our in-silico analysis we also observed that candidate microRNA biomarkers in coronary
miR-718 might regulate key genes affecting artery disease
psoriasis. Apart from in vitro validations regarding

Publications

Inhibition of microRNA-128-3p attenuates hypercholesterolemia in mouse model. Chandra A, Sharma K, Pratap K, Singh
V, Saini N. Life Sci. 2021 Jan 1;264:118633.

Mitochondrial microRNA (MitomiRs) in cancer and complex mitochondrial diseases: current status and future
perspectives. Purohit PK, Saini N. Cell Mol Life Sci. 2021 Feb;78(4):1405-1421.

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