Page 122 - CSIR-IGIB Annual Report 2020-21

to diagnose at the early stage and distinguish from active Hp tetramer accompanied by increased
other joint diseases, thus leading to progression of levels of free hemoglobin indicated the poor
the disease which results in joint stiffness and clearance of free hemoglobin in patients with
cartilage damage. The early detection by a specific severe OA. The prime factor responsible for
biomarker may be helpful in timely initiation of decreased Hp tetramer in OA serum could be the
available therapy as well as new treatment presence of autoantibody against the beta subunit
approach to mitigate the disease progression. We of Hp monomer. LRG1 has also been found as
have applied an advanced proteomic approach to another important significant up regulated protein
find the differentially expressed proteins and in OA plasma. Further study will be carried out to
check their potential role in disease progression find the role played by the LRG1 in pathogenesis
Haptoglobin (Hp) has been found to be an of OA. The combined study of all other identified
important factor in regulating hemoglobin significant differential proteins apart from Hp and
homeostasis and inflammation in severely LRG1 will be studied for their significant
affected knee OA patients. Down regulation of contribution in understanding the etiology of OA.

Publications

Oxidative stress in autoimmune diseases: An under dealt malice. Ramani S, Pathak A, Dalal V, Paul A, Biswas S. Curr
Protein Pept Sci. 2020;21(6):611-621.

In silico studies on the phytochemical components of Murraya koenigii targeting TNF-α in rheumatoid arthritis, Deeksha
Kaloni, Debolina Chakraborty, Archana Tiwari, Sagarika Biswas, Journal of Herbal Medicine, 2020, Volume 24, 100396,
ISSN 2210-8033

Synovial Fluid cell proteomic analysis identifies up regulation of ΑlphaTaxilin proteins in rheumatoid arthritis: a potential
prognostic marker, Ashish Sarkar1, Shivani Sharma1, Prachi Agnihotri1, Tanmoy Sarkar1, Pooja Kumari1,
RajeshMalhotra2, Barun Datta3, Vijay Kumar2, Sagarika Biswas1*. J Immunol Res. 2020 Apr 23;2020:4897983.

Therapeutic potential of Dracaena cinnabari Balf. f. on high fat diet fed rats, Rupsi Kharb1, Prachi Agnihotri1 and Sagarika
Biswas. Academia Journal of Medicinal Plants 8(11): 159-170, November 2020, IF 2.6

Plasma Proteome Profiling of Coronary Artery Disease Patients: Downregulation of Transthyretin-an important event.
Monu, Kharb R, Sharma A, Chaddar MK, Yadav R, Agnihotri P, Kar A, Biswas S. Mediators Inflamm. 2020 Nov
10;2020:3429541.

A mechanistic insight of phytoestrogens used for rheumatoid arthritis: An evidence-based review. Chakraborty D, Gupta
K, Biswas S. Biomed Pharmacother. 2021 Jan;133:111039.

A review on the efficacy of phytomedicines for rheumatoid arthritis, Deeksha Kaloni1, Debolin Chakraborty1,2, , Sagarika
Biswas1*, Academia Journal of Medicinal Plants, 2021,Vol 21 , Issue 6, Page: [611 - 621], IF 2.6

Post translational modification and its pathologic association in rheumatoid arthritis: A brief perspective. Vasudevan V,
Agnihotri P, Biswas S. Curr Protein Pept Sci. 2021;22(7):548-558.

Biomarkers of joint damage in osteoarthritis: current status and future directions. Kumavat R, Kumar V, Malhotra R,
Pandit H, Jones E, Ponchel F, Biswas S. Mediators Inflamm. 2021 Mar 9;2021:5574582.

Poor clearance of free hemoglobin due to lower active haptoglobin availability is associated with osteoarthritis
inflammation. Sarkar A, Monu, Kumar V, Malhotra R, Pandit H, Jones E, Ponchel F, Biswas S. J Inflamm Res. 2021 Mar
18;14:949-964.

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