Page 56 - CSIR-IGIB Annual Report 2020-21

from various regions of the brain like cerebrum, corresponding to different regions of the brain,
substantia nigra, pituitary, temporal lobe, we identified proteoforms that exhibited
corpus callosum and hippocampus to create a distinct patterns of expression in the different
comprehensive landscape of brain tissue- tissues. This study resulted in a rich set of data
specific proteoforms. We developed a that was compiled as HuBSProt, a dedicated MS-
proteoform identification pipeline for bottom- level data resource, for finding and comparing
up proteomics data which incorporates proteoforms for the brain proteomics
information from different proteomic and community. HuBSProt can be utilized as a
transcriptomic sources like neXtProt and healthy reference brain proteoform map to
GENCODE in the search database. Using 25 identify the proteoforms expressing in various
brain mass spectrometry data sets neurological disorders.

Publications
A rapid and sensitive method to detect SARS-CoV-2 virus using targeted-mass spectrometry. Singh P, Chakraborty
R, Marwal R, Radhakrishan VS, Bhaskar AK, Vashisht H, Dhar MS, Pradhan S, Ranjan G, Imran M, Raj A, Sharma U,
Singh P, Lall H, Dutta M, Garg P, Ray A, Dash D, Sivasubbu S, Gogia H, Madan P, Kabra S, Singh SK, Agrawal A, Rakshit
P, Kumar P, Sengupta S. J Proteins Proteom. 2020;11(3):159-165.

Integrated genomic view of SARS-CoV-2 in India. Kumar P, Pandey R, Sharma P, Dhar MS, A V, Uppili B, Vashisht H,
Wadhwa S, Tyagi N, Fatihi S, Sharma U, Singh P, Lall H, Datta M, Gupta P, Saini N, Tewari A, Nandi B, Kumar D, Bag
S, Gahlot D, Rathore S, Jatana N, Jaiswal V, Gogia H, Madan P, Singh S, Singh P, Dash D, Bala M, Kabra S, Singh S,
Mukerji M, Thukral L, Faruq M, Agrawal A, Rakshit P. Wellcome Open Res. 2020 Aug 3;5:184.

Role of VapBC12 toxin-antitoxin locus in cholesterol-induced mycobacterial persistence. Talwar S, Pandey M,
Sharma C, Kutum R, Lum J, Carbajo D, Goel R, Poidinger M, Dash D, Singhal A, Pandey AK. mSystems. 2020 Dec
15;5(6):e00855-20.

IndiGenomes: a comprehensive resource of genetic variants from over 1000 Indian genomes. Jain A, Bhoyar RC,
Pandhare K, Mishra A, Sharma D, Imran M, Senthivel V, Divakar MK, Rophina M, Jolly B, Batra A, Sharma S, Siwach
S, Jadhao AG, Palande NV, Jha GN, Ashrafi N, Mishra PK, A K V, Jain S, Dash D, Kumar NS, Vanlallawma A, Sarma RJ,
Chhakchhuak L, Kalyanaraman S, Mahadevan R, Kandasamy S, B M P, Rajagopal RE, J ER, P ND, Bajaj A, Gupta V,
Mathew S, Goswami S, Mangla M, Prakash S, Joshi K, S S, Gajjar D, Soraisham R, Yadav R, Devi YS, Gupta A, Mukerji
M, Ramalingam S, B K B, Scaria V, Sivasubbu S. Nucleic Acids Res. 2021 Jan 8;49(D1):D1225-D1232.

Comparative genomic analysis of Mycobacteriaceae reveals horizontal gene transfer-mediated evolution of the
CRISPR-Cas system in the Mycobacterium tuberculosis complex. Singh A, Gaur M, Sharma V, Khanna P, Bothra A,
Bhaduri A, Mondal AK, Dash D, Singh Y, Misra R. mSystems. 2021 Jan 19;6(1):e00934-20.

Preprints

Validation of expert system enhanced deep learning algorithm for automated screening for COVID-Pneumonia on
chest X-rays Prashant Sadashiv Gidde, Shyam Sunder Prasad, Ajay Pratap Singh, Nitin Bhatheja, Satyartha Prakash,
Prateek Singh, Aakash Saboo, Rohit Thakar, Salil Gupta, Sumeet Saurav, M V Raghunandanan, Amritpal Singh, Viren
Sardana, Harsh Mahajan, Arjun Kalyanpur, Atanendu Shekhar Mandal, Vidur Mahajan, Anurag Agrawal, Anjali
Agrawal, Vasantha Kumar Venugopal, Sanjay Singh, Debasis Dash medRxiv 2020.10.20.20213793

Genetic differences between extreme and composite constitution types from whole exome sequences reveal
actionable variations Tahseen Abbas, Rintu Kutum, Rajesh Pandey, Pushkar Dakle, Ankita Narang, Vijeta
Manchanda, Rutuja Patil, Dheeraj Aggarwal, Gourja Bansal, Pooja Sharma, Gaura Chaturvedi, Bhushan Girase,
Ankita Srivastava, Sanjay Juvekar, Debasis Dash, Bhavana Prasher, Mitali Mukerji bioRxiv 2020.04.24.059006

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