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AIS

缺血性腦中風

使用間質幹細胞治療30個月後，病灶縮小且未出現不良反應

以一名 55 歲因急性中風導致左上肢和下肢癱瘓的臨床案例，間隔 8 天經由靜脈輸注兩
次間質幹細胞，患者經移植後 65 週後沒有出現不良反應。
Ahn H et al. MSCs treatment of acute ischemic stroke

W J S C World Journal of

Stem Cells

Submit a Manuscript: https://www.f6publishing.com World J Stem Cells 2021 August 26; 13(8): 1151-1159
DOI: 10.4252/wjsc.v13.i8.1151 ISSN 1948-0210 (online)
CASE REPORT
Treatment of acute ischemic stroke by minimally manipulated
umbilical cord-derived mesenchymal stem cells transplantation: A
case report

經過第一次幹細胞治療後 30 個月時患者的腦部電腦斷層掃描圖像，病灶大小從 3 公分
Figure 3 National Institute of Health Stroke Scale score of patient. The patient’s National Institute of Health Stroke Scale score gradually decreased for
Hyunjun Ahn, Sang Yeon Lee, Won Ju Jung, Kye-Ho Lee
60 wk after the first treatment. NIHSS: National Institute of Health Stroke Scale.
×2 公分縮小到 0.6 公分 ×0.3 公分。白色橢圓部份表示病變部位。
ORCID number: Hyunjun Ahn 0000- Hyunjun Ahn, Sang Yeon Lee, Kye-Ho Lee, bio Beauty&Health Company (bBHC)-Stem Cell
0002-5550-8325; Sang Yeon Lee Treatment & Research Institute (STRI), Seoul 04420, South Korea
0000-0003-4394-6958; Won-Ju Jung
0000-0002-4966-3118; Kye-Ho Lee Won Ju Jung, 97.7 Beauty&Health (B&H) Clinics, Seoul 04420, South Korea
0000-0001-8241-6402.
Corresponding author: Kye-Ho Lee, PhD, bio Beauty&Health Company (bBHC) - Stem Cell
Author contributions: Ahn H, Lee Treatment & Research Institute (STRI), 72 UN village-gil Yongsan-gu, Seoul 04420, South
SY, Jung WJ, and Lee KH designed Korea. khlee@stc365.com
the reports; Ahn H and Jung WJ
collected the patients’ clinical data;
Ahn H, Lee SY, and Jung WJ Abstract
analyzed the data; Ahn H wrote BACKGROUND
the manuscript; Lee KH provided Stroke is one of the major causes of disability and death worldwide. Some
professional advice and revised the treatments for stroke exist, but existing treatment methods have limitations such
manuscript; all authors issued final as difficulty in the regeneration of damaged neuronal cells of the brain. Recently,
Figure 4 Brain computed tomography images of patient after minimally manipulated human umbilical cord-derived mesenchymal stem
approval for the version to be
mesenchymal stem cells (MSCs) have been studied as a therapeutic alternative for
MM-UC-MSC 移植後之患者腦部電腦斷層掃描圖
submitted.
cells transplantation. These are brain computed tomography images of patient at 30 mo after first transplantation. The lesion size decreased from 3 cm × 2 cm to
stroke, and various preclinical and case studies have been reported.
0.6 cm × 0.3 cm. The white ovals indicate the lesion site. LPH: Left posterior head; LAF: Left anterior frontal.
Informed consent statement: The CASE SUMMARY
patients involved in this study
A 55-year-old man suffered an acute stroke, causing paralysis in the left upper
資料來源：World Journal of Stem Cells, 13(8), 1151. 25
gave their written informed or adipose tissue. Therefore, we chose UC as the source of MSCs, as it allows the
and lower limbs. He intravenously transplanted the minimally manipulated
consent authorizing disclosure of harvesting of an adequate number of cells for transplantation without culture[28].
human umbilical cord-derived MSCs (MM-UC-MSCs) twice with an 8-d interval.
At 65 wk after transplantation, the patient returned to his previous occupation as
protected health information. Although UC-MSCs are allogeneic cells, immune rejection is rare, as MSCs can
regulate immune responses[27,43]. Also, MSCs are used as an immunosuppressant by
a veterinarian with no adverse reactions.
Conflict-of-interest statement: All itself[45,46]. Based on this previous study, no immunosuppressants were used
CONCLUSION
authors have no conflicts of throughout the treatment. Following the two transplantations of MM-UC-MSCs, the
MM-UC-MSCs transplantation potentially treats patients who suffer from acute
interest to declare. patient was monitored for 30 mo. The brain CT imaging results indicated that the
transplanted MM-UC-MSCs migrated to the striatum of the brain to restore tissue at
ischemic stroke.
CARE Checklist (2016) statement: the lesion site. This supports our hypothesis that stroke may be treated through
The authors have read the CARE intravenous transplantation of MM-UC-MSCs, and that MSCs can reliably migrate to
Key Words: Acute ischemic stroke; Behavioral disorder; Umbilical cord-derived
Checklist (2016), and the the lesion area through the BBB.
Stroke scale assessment based on the NIHSS should be interpreted with care, as it is
mesenchymal stem cells; Allogenic; Cell therapy; Minimal manipulation; Case report
manuscript was prepared and a subjective assessment. 60 wk after the first transplantation, the patient showed
revised according to the CARE gradually decreasing test scores, indicating restoration of motor ability. We assessed
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Checklist (2016). the mobility of the patient on the stroke scale and recorded the changes using video
clips. The patient's mobility was shown to have improved not only to the level of
Open-Access: This article is an
open-access article that was Core Tip: Previous results of preclinical and case studies showed the effectiveness of
selected by an in-house editor and 1156 August 26, 2021 Volume 13 Issue 8
https://www.wjgnet.com
WJSC
WJSC https://www.wjgnet.com 1151 August 26, 2021 Volume 13 Issue 8