Page 15 - Randlab Global Brochure Australian Edition

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PERMIT ONLY
Equine MetronidazoleTM
PASTE
Randlab supports responsible Antimicrobial Stewardship.
For the treatment of anaerobic bacterial and protozoal infections caused by metronidazole-sensitive organisms
This product is not registered, but is supplied under APVMA Permit. Read the permit before using. APVMA Permit No. 84510
The only metronidazole product on the equine market.
ACTIVE CONSTITUENT Metronidazole 500 mg/g
PACK SIZE 1 kg Pail
INDICATIONS
For the treatment of infections in horses caused by anaerobic bacteria such as Clostridium spp, Bacteroides spp (incl penicillin resistance B. fragilis), Fusobcterium and protozoa such as Giardia and Trichomonas spp.
For the treatment of infections where anaerobic bacteria are implicated or suspected such as pleuropneumonia, sinusitis, tooth root infections, enteritis and some cases of metritis.
“The hooves of the horse!
Oh! witching and sweet is the music earth steals from the iron-shod feet;
no whisper of love, no trilling of bird,
can stir me as hooves on the horse have stirred”.
The Hoofs of the Horses by William H. Ogilvie (Scottish-Australian poet, horseman, jackaroo, drover and contemporary of Banjo Patterson).
PRECAUTIONS
DO NOT USE in animals with renal or hepatic disorders or dysfunction.
Metronidazole is relatively non-toxic. Anorexia is common following Metronidazole use. Over-dosage (high doses or prolonged treatment beyond the specified five days) may result in CNS symptoms such as depression, ataxia, tremors, seizures and weakness. Peripheral neuropathy and impaired hepatic function have also been recorded. Rarely this may not be reversible.
Insufficient data is available on use in pregnant mares to recommend the use of the product during pregnancy.
DOSAGE AND ADMINISTRATION
Metronidazole reaches therapeutic concentrations in abscesses, bone, peritoneal fluid, milk and the CNS. It crosses the placental barrier.
Oral absorption in horses 80-100%. Rectal absorption is 30-50%.
The half-life of metronidazole is 2-4 hours in adult horses and 9-12 hours in foals.
Therapeutic concentrations of metronidazole are attained after administration per rectum in horses with gastrointestinal status or to reduce the risk of anorexia.
HORSES - Administer orally. May also be administered per rectum. Give 20mL Equine Metronidazole Paste (equivalent to 10g metronidazole) per 500kg bodyweight every 12 hours for 5 days or as directed by a veterinarian.
ADULT: 15mg/kg qid or 20mg/kg bid FOAL: 10-20mg bid
“And God took a handful of Southerly wind, blew his breath over it and created the horse”. Bedouin proverb.
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