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Infective Endocarditis: Etiology and DiagnosisCommon Causes:%u2022 Streptococci and Staphylococcus aureus%u2022 Mitral valve commonly affected%u2022 In injection drug users: Tricuspid valve involvement, often S. aureusDiagnostic Approach:%u2022 New murmur + Fever %u2192 Consider IE%u2022 Initial steps: Blood culture %u2192 EchocardiographyModified Duke Criteria:%u2022 Two major criteria, or%u2022 One major criterion and three minor criteria, or%u2022 Five minor criteria