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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

Dyslipidemia

 Dyslipidemia is elevation of plasma cholesterol, triglycerides (TGs), or both, or a
low high-density lipoprotein cholesterol (HDL-C) level that contributes to the

development of atherosclerosis

 Because lipids are insoluble in plasma, they must be transported in the circulation in the
form of lipoproteins.

 Lipoproteins transport Cholesterol, triglycerides, and phospholipids in blood
 Lipoproteins include (Chylomicrons, VLDL-C, LDL-C, IDL-C, and HDL-C)

 Lipid panel

[high cholesterol]

Total cholesterol > 190 -200mg/dL

or LDL-C > 100 mg/dL

[metabolic syndrome]

Serum TGs 150-500 mg/dL

serum HDL-C < 40 mg/dL

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