Page 183 - Biochemistry2 (08PB403)

• After carbohydrate meal Glucose is transported to portal blood to
the liver.

• About 40% of glucose passes to the blood circulation stimulating
insulin secretion and taken up by brain, muscles, adipose tissue and
liver. The remaining 60% of glucose is taken up by the liver and
converted by Glucose-6-phosphate by glucokinase.

• G-6-P will has one of the following fates in the liver:

– Conversion to glycogen (Glycogenesis) stimulated by insulin.

– Conversion to fatty acids (Lipogenesis) stimulated also by
insulin.

3- Renal Regulation

• Circulating blood glucose is filtered in glomerular filterate and
reabsorbed again by certain tubular enzymes. This saves blood

glucose from loss in urine. 187