Page 23 - Biochemistry2 (08PB403)
P. 23

2. Inhibitors of active transport:

   A) Ouabin (cardiac glycoside):
•Inhibits adenosine triphosphatase (ATPase) necessary
for hydrolysis of ATP that produces energy of sodium
pump.
•Is a plant derived toxic substance that was traditionally
used as an arrow poison in eastern Africa for both
hunting and warfare.
•Ouabain is a highly toxic compound with an LD50 of
5 mg/kg.

   B) Phlorhizin: Inhibits the binding of sodium in the
carrier protein.

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