Page 247 - Biochemistry2 (08PB403)

HDL

-High-Density Lipoproteins (HDLs) “Reverse Cholesterol
Transport” (5% triglyceride, 30% phospholipid, 45%
protein, 20% cholesterol, apo A-1 & apo A-2).
-Produced in peripheral tissues.
-HDL binds to receptors in vessel walls of extrahepatic
tissue.
-Lecithin-cholesterol acyltransferase (LCAT) converts
free cholesterol in cholesterol ester, which moves into
center of HDL particle. HDL continues to pick up
cholesterol until it is “full”.
-Cholesterol transported to liver and glands (adrenals,
ovaries, testes) for bile and hormone production.