Page 200 - Applied Pharmacognosy
P. 200
Types of Chemical markers
Chinese hamster ovary Human embryo kidney
(CHO) or Baby Hamster (HEK) cells
Kidney(BHK) cells
•Have the ability to fold proteins correctly
•Post-translational modifications (PTM) such as N-linked and O-linked
glycans essential for the biological activity and stability of many
proteins
•Glycosylate proteins at correct sites
•some sugar-transferring enzymes •PTM more similar to their natural
are lacking . counterpart
•potential immunogenic reactions •Reduced potential immunogenic
reactions
4. Plant based system :
