Page 506 - COMMUNITY PHARMACY PRACTICE
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PPIs —
e prescribed at the lowest dose and for the shortest
opriate to the condition being treated.
taper PPI therapy in patients treated with PPIs for longer
hs. For patients on a standard or high-dose PPI
ole 40 mg daily or twice daily), we decrease the dose by 50
y week.
on twice daily dosing, the initial reduction can be
by decreasing the dosing to once in the morning before
il the patient is on the lowest dose of the medication.
owest dose for one week, the patient is instructed to
he PPI.
demonstrated rebound gastric acid hypersecretion following
on of PPIs in patients with long-term use.
are not entirely clear, but appear to be due in part to the
of antral somatostatin expression, resulting in an increase in
release and subsequent disruption of normal pH-related
bition of acid secretion that occurs after a meal
