Page 177 - Pharmaceutical Analytical Chemistry III
P. 177
Saponification value
Number of mg of KOH required to neutralize the free acids
and to saponify the esters in 1 g of the substance.
SPV = FFA + combined FA
Determination
Certain weight of substance examined, reflux with known volume of
ethanolic KOH for ~ 1h, titrate excess KOH ≠ st. HCl, ph.ph ind
H2C O COR + 3KOH H2C OH
HC O COR HC OH +3RCOOK
C O COR C OH
H2 H2
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