Page 29 - Pharm.Org.Chem-I 02-06-05-101
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❖Flourination and iodination are difficult to
   perfome in the lab (Flourine reacts with
   alkanes with an explosion while Iodine
   doesn’t react with alkanes).

 ❖Chlorination of alkanes is easier than
   bromination.

53

            H2  Cl2          H2         +    H3C
    H C C CH    h   H3C C CH2Cl
                                                  CH Cl
      33             n-propyl chloride
                           45%               H3C
     n-propane
                                           isopropyl chloride
                                                      55%

                                           Sec. alkyl halide
                                                 is major

    Due to ease of abstraction
      3ry H > 2ry H > 1ry H

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