Page 101 - Pharm.Org.Chem I 05-PC101 (1)

Rearrangements in HX addition to alkenes
(1,2-methide shift)

Anti-Markovnikov’s addition of HX to alkenes

• Anti-Markovnikov’s addition occurs when peroxides (ex. H2O2)
are present in the reaction mixture
• The anti-Markovnicoff’s addition proceeds through free radical

mechanism.
Marcovnicoff’s
addition
Anti-
Marcovnicoff’s
addition

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