Page 175 - Pharm.Org.Chem I 05-PC101 (1)
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Orientation and Synthesis
• The concept of orientation in disubstitution products of
benzene can be useful in a laboratory synthesis of compounds.
• It is necessary to consider the order in which the various
substituents are introduced into the ring.
• Example 1:
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• If you do the opposite:
• The product would be a mixture of o- and p-
chloronitrobenzene.
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